The paper “Insights into the evolution of enzymatic specificity and catalysis: From Asgard archaea to human adenylate kinases” from the Wolf-Watz lab is now published in Science Advances!
Combining cryo-electron tomography with virology and cell biology, the Carlson lab published an in situ structural study of poliovirus assembly and its links to autophagy.
The first author is Selma Dahmane (Umeå) and the project was a collaboration with the National Institutes of Health (USA) and Monash University (Australia).
Read the open access paper here: https://www.nature.com/articles/s41467-022-33483-7
A new pre-print from the Berntsson lab, with Annika Breidenstein as first author, is out on bioRxiv. You can find it here!
We congratulate Dr. Lena Lassinantti, who successfully defended her thesis on the 3rd of June!
Inhibition of the master regulator of Listeria monocytogenes virulence enables bacterial clearance from spacious replication vacuoles in infected macrophages. Tran TT, Mathmann CD, Gatica-Andrades M, Rollo RF, Oelker M, Ljungberg JK, Nguyen TTK, Zamoshnikova A, Kummari LK, Wyer OJK, Irvine KM, Melo-Bolívar J, Gross A, Brown D, Mak JYW, Fairlie DP, Hansford KA, Cooper MA, Giri R, Schreiber V, Joseph SR, Simpson F, Barnett TC, Johansson J, Dankers W, Harris J, Wells TJ, Kapetanovic R, Sweet MJ, Latomanski EA, Newton HJ, Guérillot RJR, Hachani A, Stinear TP, Ong SY, Chandran Y, Hartland EL, Kobe B, Stow JL, Sauer-Eriksson AE, Begun J, Kling JC, Blumenthal A. PLoS Pathog. 2022 Jan 10;18(1):e1010166.
In this paper the crystal structures of MakA, MakB and MakE are characterized. They are proteins that are secreted via the bacterial flagellum. Together they form a tripartite toxin that lyses erythrocytes and is cytotoxic to cultured human cells. The work was lead by group Karina Persson.
We have a new publication out in Nature communications describing the cryo-EM structure of the 2-protofilament fiber of human transthyretin. The fibers we purified from vitreous body material collected by vitrectomy from the eye of a Swedish carrier of the ATTR Val30Met variant.
The 4th of Nov, 2021 at 10:00 in “Glasburen” will Melanie Oelker defend her thesis: “Disarming Bacteria: A structure-based approach to design an anti-virulence drug against Listeria monocytogenes”. Faculty opponent is Prof. Tiziano Tuccinardi, University of Pisa, Italy.
The ISB postdoc program call is now open for the round of 2021. At this stage we are inviting project proposals from PIs that wish to recruit postdocs within this program. For full details of the call and how to apply, please see https://www.biostruct.umu.se/isb-postdoctoral-program/