New pre-print out – “Structural and functional characterization of TraI from pKM101 reveals basis for DNA processing”

A new pre-print from the Berntsson lab, with Annika Breidenstein as first author, is out on bioRxiv. You can find it here!

New PhD awarded!

We congratulate Dr. Lena Lassinantti, who successfully defended her thesis on the 3rd of June!

Learn more about how virulence is regulated in Listeria monocytogenes: New publication in PLOS pathogens

Inhibition of the master regulator of Listeria monocytogenes virulence enables bacterial clearance from spacious replication vacuoles in infected macrophages. Tran TT, Mathmann CD, Gatica-Andrades M, Rollo RF, Oelker M, Ljungberg JK, Nguyen TTK, Zamoshnikova A, Kummari LK, Wyer OJK, Irvine KM, Melo-Bolívar J, Gross A, Brown D, Mak JYW, Fairlie DP, Hansford KA, Cooper MA, Giri R, Schreiber V, Joseph SR, Simpson F, Barnett TC, Johansson J, Dankers W, Harris J, Wells TJ, Kapetanovic R, Sweet MJ, Latomanski EA, Newton HJ, Guérillot RJR, Hachani A, Stinear TP, Ong SY, Chandran Y, Hartland EL, Kobe B, Stow JL, Sauer-Eriksson AE, Begun J, Kling JC, Blumenthal A. PLoS Pathog. 2022 Jan 10;18(1):e1010166.

New publication in PNAS describing the tripartite cytotoxin MakABE from V. cholerae

In this paper the crystal structures of MakA, MakB and MakE are characterized. They are proteins that are secreted via the bacterial flagellum. Together they form a tripartite toxin that lyses erythrocytes and is cytotoxic to cultured human cells. The work was lead by group Karina Persson.

https://doi.org/10.1073/pnas.2111418118

New publication describing the amyloid structure of human transthyretin

We have a new publication out in Nature communications describing the cryo-EM structure of the 2-protofilament fiber of human transthyretin. The fibers we purified from vitreous body material collected by vitrectomy from the eye of a Swedish carrier of the ATTR Val30Met variant.

https://www.nature.com/articles/s41467-021-27481-4

Congratulations Dr Oelker!

Thesis defense: Melanie Oelker

The 4th of Nov, 2021 at 10:00 in “Glasburen” will Melanie Oelker defend her thesis: “Disarming Bacteria: A structure-based approach to design an anti-virulence drug against Listeria monocytogenes”. Faculty opponent is Prof. Tiziano Tuccinardi, University of Pisa, Italy.

ISB postdoc program – Calls out for project proposals from PIs

The ISB postdoc program call is now open for the round of 2021. At this stage we are inviting project proposals from PIs that wish to recruit postdocs within this program. For full details of the call and how to apply, please see https://www.biostruct.umu.se/isb-postdoctoral-program/

New publication on the regulation of conjugation

We have a new publication out in mSphere regarding how enterococcal PrgU provides additional layer of complexity to pheromone controlled conjugative plasmids in Gram-positive bacteria!

https://journals.asm.org/doi/10.1128/mSphere.00264-21

Postdoc fellowship available in Karina Persson’s group- apply by June 18

Apply here: Postdoc fellowship available in Karina Persson’s lab

If you are interested in membrane proteins and structural biology and want to use a blend mentods: X-ray crystallography, cryo-EM and protein chemistry- please apply. It is a fellowship for two years funded by Carl Trygger foundations.