In collaboration with the Cava lab, Josy ter Beek solved the structure of a recptor that recognizes D-amino acid. For the full publiction in Nature Micorbiology, see here.
The paper by Sun et al is out in eLife, and can be found here!
The transcription factor protein CodY is a global transcription factor, found in almost all low G + C Gram-positive bacteria, where it functions as a regulator of transcription for several hundred genes. Importantly, CodY also directly or indirectly control the expression of essential virulence factors. This paper highlights mechanistic similarities and differences between CodY proteins, important knowledge for therapeutic targeting of the virulence regulator CodY.
We welcome Leon to our lab!! Leon will work on adenylate kinases from extreme habitats!
The paper “Insights into the evolution of enzymatic specificity and catalysis: From Asgard archaea to human adenylate kinases” from the Wolf-Watz lab is now published in Science Advances!
Combining cryo-electron tomography with virology and cell biology, the Carlson lab published an in situ structural study of poliovirus assembly and its links to autophagy.
The first author is Selma Dahmane (Umeå) and the project was a collaboration with the National Institutes of Health (USA) and Monash University (Australia).
Read the open access paper here: https://www.nature.com/articles/s41467-022-33483-7
A new pre-print from the Berntsson lab, with Annika Breidenstein as first author, is out on bioRxiv. You can find it here!
We congratulate Dr. Lena Lassinantti, who successfully defended her thesis on the 3rd of June!
Inhibition of the master regulator of Listeria monocytogenes virulence enables bacterial clearance from spacious replication vacuoles in infected macrophages. Tran TT, Mathmann CD, Gatica-Andrades M, Rollo RF, Oelker M, Ljungberg JK, Nguyen TTK, Zamoshnikova A, Kummari LK, Wyer OJK, Irvine KM, Melo-Bolívar J, Gross A, Brown D, Mak JYW, Fairlie DP, Hansford KA, Cooper MA, Giri R, Schreiber V, Joseph SR, Simpson F, Barnett TC, Johansson J, Dankers W, Harris J, Wells TJ, Kapetanovic R, Sweet MJ, Latomanski EA, Newton HJ, Guérillot RJR, Hachani A, Stinear TP, Ong SY, Chandran Y, Hartland EL, Kobe B, Stow JL, Sauer-Eriksson AE, Begun J, Kling JC, Blumenthal A. PLoS Pathog. 2022 Jan 10;18(1):e1010166.
In this paper the crystal structures of MakA, MakB and MakE are characterized. They are proteins that are secreted via the bacterial flagellum. Together they form a tripartite toxin that lyses erythrocytes and is cytotoxic to cultured human cells. The work was lead by group Karina Persson.