Mobile Genetic Elements in Staphylococcus aureus

Phage Therapy

Ignacio Mir-Sanchis

We are interested in understanding staphylococcal pathogenesis. Specifically, we study gene expression and DNA replication using staphylococcal bacteriophages and other mobile genetic elements involved in antimicrobial resistance. Additionally, we are interested in phage therapy as an alternative to antibiotics or as coadyuvants.

The use of structural biology allows us to understand how different biological mechanisms work, while the use of genetics and molecular biology approaches aid us to place the mechanistic understanding in a much broader and biological context.

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Image: Left, two dimensional averaged images of a protein called PriRe5 generated by electron cyo-microscopy. Center and right, Model and cryoEM map of PriRep5. For more info please see the publication Qiao et al, Nucleic Acids Research 2022.