Complete list of publications

Original articles:

1. Björklund, S., Hjortsberg, K., Johansson, E., and Thelander, L. (1993) Structure and promoter characterization of the gene encoding the large subunit (R1 protein) of mouse ribonucleotide reductase. Proc. Natl. Acad. Sci. USA90:11322-11326

2. Johansson, E., Skogman, E., and Thelander, L. (1995) The TATA-less promoter of mouse ribonucleotide reductase R1 gene contains a TFII-I binding initiator element essential for cell cycle regulated transcription. J. Biol. Chem. 270:30162-30167 

3. Filatov, D., Björklund, S., Johansson, E., and Thelander, L. (1996) Induction of the mouse ribonucleotide reductase R1 and R2 genes in response to DNA damage by UV light. J. Biol. Chem. 271:23698-23704

4. Johansson, E., Hjortsberg, K., and Thelander, L. (1998) Two YY-1-binding proximal elements regulate the promoter strength of the TATA-less mouse ribonucleotide reductase R1 gene. J. Biol. Chem. 273:29816-29821

5. Kamath-Loeb, A.S., Johansson, E., Burgers, P.M.J., and Loeb, L.A. (2000) Functional interaction between the Werner Syndrome protein and DNA polymerase . Proc. Natl. Acad. Sci. USA 97:4603-4608 

6. Kamath-Loeb, A.S., Loeb, L.A., Johansson, E., Burgers, P.M.J., and Fry, M. (2001) Interactions between the Werner Syndrome helicase and DNA polymerase  specifically facilitate the copying of tetraplex and hairpin structures of the d(CGG)n trinucleotide repeat sequence.J. Biol. Chem.276: 16439-16446. IF=7,3

7. Haracska, L., Unk, I., Johnson, R.E., Johansson, E., Burgers, P.M.J., Prakash, S., and Prakash, L. (2001) Roles of yeast DNA polymerase  and ζ and of Rev1 in the bypass of abasic sites. Genes & Dev. 15:945-954 

8. Johansson, E., Majka, J., and Burgers, P.M.J. (2001) Structure of DNA polymerase δ from S. cerevisiae. J. Biol. Chem. 276:43824-43828 

9. Chilkova, O., Jonsson, B-H, and Johansson, E. (2003) The quaternary structure of DNA polymerase  from S. cerevisiae. J Biol. Chem. 278:14082-14086

10. Shcherbakova, P.V., Pavlov, Y.I., Chilkova, O., Rogozin, I.B., Johansson, E., and Kunkel, T.A. (2003) Unique error signature of the four-subunit yeast DNA polymerase epsilon. J. Biol. Chem. 278:43770-43780

11. Johansson, E., Garg, P., and Burgers, P.M.J. (2004) The Pol32 subunit of DNA polymerase δ contains separable domains for processive replication and PCNA binding. J. Biol. Chem. 279: 1907-1915

12. McCulloch, S.D., Kokoska, R.J., Garg, P., Chilkova, O., Johansson, E., Burgers, P.M.J., and Kunkel, T.A. (2004) Enzymatic switching for efficient and accurate translesion DNA replication. Nucleic Acids Res. 32:4665-4675

13. Garg, P., Stith, C.M., Sabouri, N., Johansson, E., and Burgers, P.M.J (2004) Idling by DNA polymerase  maintains a ligatable nick during lagging strand DNA replication. Genes & Dev. 18:2764-2773

14. Fortune, J.M., Pavlov, Y.I., Welch, C.M., Johansson, E., Burgers, P.M.J., and Kunkel, T.A. (2005)  Saccharomyces cerevisiae DNA polymerase  : High fidelity for base substitutions but lower fidelity for single-and multi-base deletions. J. Biol. Chem. 280:29980-29987

15. Asturias, F.J., Cheung, I.K., Sabouri, N., Chilkova, O., Wepplo, D., and Johansson, E. (2006) Structure of Saccharomyces cerevisiae DNA polymerase ε by cryo electron microscopy. Nature Structural & Molecular Biology 13:35 – 43 

16. Pursell, Z.F., Isoz, I., Lundström, E.-B., Johansson, E., and Kunkel, T.A. (2007)  Regulation of B Family DNA polymerase fidelity by a conserved active site residue: characterization of M644W, M644L and M644F mutants of yeast DNA polymerase epsilon. Nucleic Acids Res. 35:3076-3086

17. Pursell, Z.F., Isoz, I., Lundström, E.-B., Johansson, E., and Kunkel, T.A. (2007) Yeast DNA polymerase epsilon participates in leading-strand DNA replication. SCIENCE   317: 127-130

18. Chilkova,O., Stenlund, P., Isoz, I., Stith, C.M., Grabowski, P.M., Lundström, E-B., Burgers, P.M., and Johansson, E. (2007) The eukaryotic leading and lagging strand DNA polymerases are loaded onto the primer-end via separate mechanisms but have comparable processivity in the presence of PCNA. Nucleic Acids Res. 35: 6588 – 6597

19. Wardle, J., Burgers, P.M.J., Cann, I.K.O., Darley, K., Heslop, P. Johansson, E., Lin, L.-J., McGlynn, P., Sanvoisin, J., Stith, C.M., and Connolly, B.A. (2008) Uracil recognition by replicative DNA polymerase is limited to the archaea, not occurring with bacteria and eukarya. Nucleic Acids Res. 36:705-711

20. Sabouri, N., Viberg, J., Kumar, D., #Johansson, E., and #Chabes, A. (2008) Evidence for lesion bypass by yeast replicative DNA polymerases during DNA damage. Nucleic Acids Res. 36:5660-7

21. Sabouri, N., and Johansson, E. (2009) Translesion synthesis of abasic sites by yeast DNA polymerase epsilon. J. Biol. Chem. 284:331555-31563

22. Nick McElhinny, SA., Watts, B.E., Kumar, D., Watt, DL., Lundström, E.B., Burgers, PM., Johansson, E., Chabes, A., Kunkel, TA. (2010) Abundant ribonucleotide incorporation into DNA by yeast replicative polymerases. Proc. Natl. Acad. Sci. USA 107:4949-54

23. Nick McElhinny, S.A., Kumar, D., Clark, A.B., Watt, D.L., Watts, B.E.,  Lundström, E.B., Johansson, E., Chabes, A., Kunkel, TA. (2010) The consequences of rNMP incorporation into DNA in vivo by yeast DNA polymerase epsilon. Nature Chemical Biology 10:774-81

24. Aksenova, A., Volkov, K., Macheluch, J., Pursell, Z.F.,  Rogozin, I.B., Kunkel, T.A., Pavlov, Y.I. and Johansson, E. (2010)  Mismatch repair-independent increase in spontaneous mutagenesis in yeast lacking non-essential subunits of DNA polymerase epsilon. PLoS Genetics 6:e1001209

25. Watt, D.L., Johansson, E. Burgers, P.M. and Kunkel, T.A. (2011) Replication of ribonucleotide-containing DNA templates by yeast replicative polymerases. DNA repair 10:897-902 

26. Hogg, M, Sauer-Eriksson, A.E., and Johansson, E. (2012) Promiscuous DNA synthesis by human DNA polymerase θ. Nucleic Acids Res.40: 2611-2622 

27. Williams, J.S., Clausen, A.R. Nick McElhinny, S.A.,Watts, B.E, Johansson, E., and Kunkel, T.A. (2012) Proofreading of ribonucleotides inserted into DNA by yeast DNA polymerase . DNA Repair 11:649-56 

28. Sparks, J.L., Chon, H., Cerritelli, S.M., Kunkel, T.A., Johansson, E., Crouch, R.J., and Burgers, P.M. (2012) RNase H2-Initiated Ribonucleotide Excision Repair. Molecular Cell. 47:980-986 

29. Isoz, I., Persson, U., Volkov, K., and Johansson, E. (2012) The C-terminus of Dpb2 is required for interaction with Pol2 and for cell viability. Nucleic Acids Res. 40:11545-53

30. Hogg, M., Osterman, P., Bylund, G.O., Ganai, R.A., Lundström, E.-B., Sauer- Eriksson, A.E. and Johansson, E. (2014) Structural basis for processive DNA synthesis by yeast DNA polymerase ε.  Nature Structural & Molecular Biology 21:49-55

The article was discussed in: Zahn and Doublié, News & Views, Nature Structural & Molecular Biology 21:12-14 and Riddihough, Editor´s choice – highlights of the recent literature  Science 343:5

Zahn and Doublié, News & Views, Nature Structural & Molecular Biology 21:12-14 and Riddihough, Editor´s choice – highlights of the recent literature  Science 343:5

31. Yousefzadeh MJ, Wyatt DW, Takata K, Mu Y, Hensley SC, Tomida J, Bylund GO, Doublié S, Johansson E, Ramsden DA, McBride KM, and Wood RD. (2014) Mechanism of Suppression of Chromosomal Instability by DNA Polymerase POLQ. PLoS Genet. 10:e1004654 

32. Ganai, R.A., Bylund, G.O., and Johansson, E. (2015) Switching between polymerase and exonuclease sites in DNA polymerase ε. Nucleic Acids Res 43:932-42

33. Ganai, R.A., Osterman, P., and Johansson, E. (2015) Yeast DNA polymerase ε catalytic core and holoenzyme have comparable catalytic rates. J. Biol. Chem. 290:3825-35

34. Rentoft, M., Lindell, K., Tran, P., Chabes, A.-L., Buckland, R., Watt, D., Marjavaara, L., Nilsson, A.-K., Melin, B., Trygg, J., Johansson, E., and Chabes, A. (2016) Heterozygous colon cancer-associated mutations of SAMHD1 have functional significance. Proc. Natl. Acad. Sci. USA 113:4723-28

35. Ganai, R.A., Zhang, X.P., Heyer, W.D., and Johansson, E. (2016) Strand displacement synthesis by yeast DNA polymerase ε. Nucleic Acids Res. 44:8229-40

36. Yu, C., Gan, H., Serra-Cardona, A., Zhang, L., Gan, S., Sharma, S., Johansson, E., Chabes, A., Xu, R.M., and Zhang, Z. (2018) A mechanism for preventing asymmetric histone segregation onto replicating DNA strands Science  361: 1386-1389

37. Parkash, V., Kulkarni, Y., ter Beek, J., Shcherbakova, P.V., Kamerlin, S.C.L., and Johansson, E.  (2019) Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase epsilon. Nature Communications 10:373

Review articles/ book chapters

1. Johansson, E., Björklund, S., and Thelander, L. Gene structure and regulation of the expression of the R1 and R2 subunits of mouse ribonucleotide reductase. Purine and Pyrimidine Metabolism in Man VIII, pp 721-724, Eds A. Sahota and M.Taylor, Plenum Press, New York, 1995

2. Filatov, D., Ingemarsson, R., Johansson, E., Rova, U., and Thelander, L . Mouse ribonucleotide reductase-from genes to proteins. Biochem. Soc. Trans., 23 (4):903-905, 1995 

3. Johansson, E., and MacNeill, SA. (2010) The eukaryotic replicative DNA polymerases take shape. Trends in Biochemical Sciences (TiBS) 35:339-47. IF=10,4

4. Johansson, E., Speck, C., and Chabes, A. (2011) A top-down view on DNA replication and recombination from 9,000 feet above sea level. Meeting report. Genome Biology 12:304 

5. Hogg, M., and Johansson, E. (2012) DNA polymerase . The Eukaryotic Replisome: A Guide to Protein Structure and Function. Springer Link, edited by Stuart MacNeill, Subcell Biochem. 2012;62:237-57.  Invited review

6. Johansson, E and Nicholas Dixon  (2013) Replicative DNA polymerases. DNA replication / edited by Stephen D. Bell, Marcel Mechali, and Melvin L. DePamphilis. Cold Spring Harbor perspectives in biology Jun 1;5(6). pii: a012799. doi: 10.1101/cshperspect.a012799.  Invited review 

7. Ganai, R.A., and Johansson, E. (2016) DNA replication – a matter of fidelity. Molecular Cell  62: 745-755  Invited review


1. Erik Johansson. Transcriptional regulation of the mouse ribonucleotide reductase R1 gene. Umeå University Medical Dissertations, New Series No 510 – ISSN 0346-6612. (1997)