Structural insights into CodY activation and DNA recognition published in Nucleic Acid Research

The transcription factor protein CodY is a global transcription factor, found in almost all low G + C Gram-positive bacteria, where it functions as a regulator of transcription for several hundred genes. Importantly, CodY also directly or indirectly control the expression of essential virulence factors. This paper highlights mechanistic similarities and differences between CodY proteins, important knowledge for therapeutic targeting of the virulence regulator CodY.