Entries by Elisabeth Sauer-Eriksson

Structural insights into CodY activation and DNA recognition published in Nucleic Acid Research

https://doi.org/10.1093/nar/gkad512 The transcription factor protein CodY is a global transcription factor, found in almost all low G + C Gram-positive bacteria, where it functions as a regulator of transcription for several hundred genes. Importantly, CodY also directly or indirectly control the expression of essential virulence factors. This paper highlights mechanistic similarities and differences between CodY proteins, important […]

Learn more about how virulence is regulated in Listeria monocytogenes: New publication in PLOS pathogens

Inhibition of the master regulator of Listeria monocytogenes virulence enables bacterial clearance from spacious replication vacuoles in infected macrophages. Tran TT, Mathmann CD, Gatica-Andrades M, Rollo RF, Oelker M, Ljungberg JK, Nguyen TTK, Zamoshnikova A, Kummari LK, Wyer OJK, Irvine KM, Melo-Bolívar J, Gross A, Brown D, Mak JYW, Fairlie DP, Hansford KA, Cooper MA, […]

Thesis defense: Melanie Oelker

The 4th of Nov, 2021 at 10:00 in “Glasburen” will Melanie Oelker defend her thesis: “Disarming Bacteria: A structure-based approach to design an anti-virulence drug against Listeria monocytogenes”. Faculty opponent is Prof. Tiziano Tuccinardi, University of Pisa, Italy.

New Article in Cell Reports: Control of bacterial virulence through the peptide signature of the habitat

Krypotou, E., Scortti, M., Grundström, C., Oelker, M., Luisi, B.F., Sauer-Eriksson, A.E. & Vázquez-Boland, J. Control of bacterial virulence through the peptide signature of the habitat. (2019) Cell Reports, 26, 1815-1827. We identify a major control mechanism of Listeria virulence based on antagonistic regulation by environmental peptides.Activity levels of the virulence regulator PrfA depend on […]