Inhibition of the master regulator of Listeria monocytogenes virulence enables bacterial clearance from spacious replication vacuoles in infected macrophages. Tran TT, Mathmann CD, Gatica-Andrades M, Rollo RF, Oelker M, Ljungberg JK, Nguyen TTK, Zamoshnikova A, Kummari LK, Wyer OJK, Irvine KM, Melo-Bolívar J, Gross A, Brown D, Mak JYW, Fairlie DP, Hansford KA, Cooper MA, […]
In this paper the crystal structures of MakA, MakB and MakE are characterized. They are proteins that are secreted via the bacterial flagellum. Together they form a tripartite toxin that lyses erythrocytes and is cytotoxic to cultured human cells. The work was lead by group Karina Persson.
We have a new publication out in Nature communications describing the cryo-EM structure of the 2-protofilament fiber of human transthyretin. The fibers we purified from vitreous body material collected by vitrectomy from the eye of a Swedish carrier of the ATTR Val30Met variant. https://www.nature.com/articles/s41467-021-27481-4
The 4th of Nov, 2021 at 10:00 in “Glasburen” will Melanie Oelker defend her thesis: “Disarming Bacteria: A structure-based approach to design an anti-virulence drug against Listeria monocytogenes”. Faculty opponent is Prof. Tiziano Tuccinardi, University of Pisa, Italy.
We are looking for a motivated research student with a strong interest in structure biology, biophysics and biochemistry. Job descriptions and general specifications of the PhD position are available on the following recruitment website: Application deadline is 10th Dec 2020 Best Regards, Elisabeth Sauer-Eriksson
Krypotou, E., Scortti, M., Grundström, C., Oelker, M., Luisi, B.F., Sauer-Eriksson, A.E. & Vázquez-Boland, J. Control of bacterial virulence through the peptide signature of the habitat. (2019) Cell Reports, 26, 1815-1827. We identify a major control mechanism of Listeria virulence based on antagonistic regulation by environmental peptides.Activity levels of the virulence regulator PrfA depend on […]
On June 1st Artur Dingeldein successfully defended his PhD thesis. Congratulations Artur!
Zhang J, Grundström C, Brännström K, Iakovleva I, Lindberg M, Olofsson A, Andersson PL, Sauer-Eriksson AE. Environ Sci Technol. 2018, 52, 11865-11874.
Kulén M, Lindgren M, Hansen S, Cairns AG, Grundström C, Begum A, van der Lingen I, Brännström K, Hall M, Sauer UH, Johansson J, Sauer-Eriksson AE, Almqvist F. J Med Chem. 2018 May 10;61(9):4165-4175.
