PhD student position available in the group of Ronnie Berntsson

We have a PhD student position available, for structural and functional studies of bacterial Type 4 Secretion Systems.
We are looking for an enthusiastic and highly motivated individual who has an interest in large protein machineries. We use biochemistry, molecular biology, x-ray crystallography and cryo-EM to study Type 4 Secretion Systems, mainly of Gram-positive origin.


The Berntsson lab is part of the integrated structural biology network at Umeå University, and from the 1st of December also part of the Wallenberg Center for Molecular Medicine. We are well equipped with state of the art technologies, both for crystallography and EM, including a nanodrop crystallisation robots, Formulatrix crystallisation hotel, an EM facility with Titan Krios and Scios Dualbeam for FIB-milling, as well as other strong facilities.


For further information, and to apply, please go to the official ad:


Informal inquiries about the position can be directed to me at ronnie.berntsson@umu.se. Applications must be sent in via the online recruitment system, with a deadline at 7th of December.

PhD defence Artur Dingeldein

On June 1st Artur Dingeldein successfully defended his PhD thesis.

Congratulations Artur!

New article out: Interspecies Variation between Fish and Human Transthyretins in Their Binding of Thyroid-Disrupting Chemicals

Zhang J, Grundström C, Brännström K, Iakovleva I, Lindberg M, Olofsson A, Andersson PL, Sauer-Eriksson AE.

Environ Sci Technol. 2018, 52, 11865-11874.

New article out: Structure-Based Design of Inhibitors Targeting PrfA, the Master Virulence Regulator of Listeria monocytogenes.

Kulén M, Lindgren M, Hansen S, Cairns AG, Grundström C, Begum A, van der Lingen I, Brännström K, Hall M, Sauer UH, Johansson J, Sauer-Eriksson AE, Almqvist F. J Med Chem. 2018 May 10;61(9):4165-4175.

New article out: PrgB Promotes Aggregation, Biofilm Formation, and Conjugation through DNA Binding and Compaction

The Berntsson group just published a new article titled “PrgB Promotes Aggregation, Biofilm Formation, and Conjugation through DNA Binding and Compaction”, with the first author Dr. Andreas Schmitt. Check it out here at Molecular Microbiology.

 

Practical Course on Rapid Cloning, Protein Expression, and Purification – 28/2-9/3 2018

Practical Course on Rapid Cloning, Protein Expression, and Purification  

CPEP 18 – 3 ECTS, 28th  February – 9th March 2018

  1. The deadline is extended until 16 February
  2. The course is Free of Charge the fee has been cancelled
    (acceptance  is on a first come first serve basis)

Max number of participants 12.

More information on our course website here:

http://www.kbc.umu.se/english/courses/cpep-course/

Contact and course organiser: Uwe.Sauer@umu.se, Protein Expertise Platform at Umeå University (PEP)

PhD defence Roland Locmelis

On February 5th Roland Locmelis successfully defended his PhD thesis.

Congratulations Roland!

PhD defence: Roland Locmelis, 2018-02-05

Titel: “Structural biology studies of thylacoid lumen proteins required for photosystem II assembly and function”

Date: 5th of February

Time: 10:00

Place: N430, Naturvetarhuset UmU

Supervisor: Uwe H. Sauer

Open position as postdoc in NMR spectoscopy, Wolf-Watz lab

We have an opening for a postdoc in enzyme dynamics. The salary is provided as a fellowship.

Postdoc position available in the group of Ronnie Berntsson

Postdoctoral fellowship to study Type 4 Secretion System

 

Project description

The Berntsson lab at the department of Medical Biochemistry and Biophysics at Umeå University, Sweden, is looking to recruit a postdoctoral fellow to study the structural and functional aspects of Type 4 Secretion Systems. These large protein complexes are responsible for horizontal gene transfer between bacteria. As such, they facilitate the spread of, among other genes, antibiotic resistance between bacteria, both intra- and interspecies.

 

The overall goal of this particular project is to structurally and functionally characterize the integral membrane proteins that make up the conjugation channel. The project will involve molecular biology, biochemistry and structural biology techniques, with an early emphasis on the functional characterization of these proteins and their complexes.

 

Qualifications

The applicant must possess a PhD, or another diploma deemed equivalent to a PhD, within molecular biology, biochemistry, structural biology or a related field. Furthermore, the applicant shall have practical experience and expertise of cloning and protein production in bacteria. The applicant should preferably be experienced with functional studies of (membrane) proteins using various molecular biology and biochemical methods, such as ITC, SPR, fluorescence spectroscopy and microscopy. Previous experience of working with membrane proteins is an advantage, as is previous experience of fluorescence microscopy and electron microscopy. The applicant must have a very good level of English, both written and spoken. The applicant is also expected to be a good team player, but should also be able to work independently.

 

Application

The application should consist of the following:

  1. A short (maximum 1 A4 page) cover letter, explaining the motivation to apply for the position.
  2. The Curriculum Vitae of the applicant, including a list of published peer-reviewed articles.
  3. Copies of the PhD diploma (or equivalent).
  4. Contact details for three references, of which one should be your PhD supervisor.

 

Compile all files into a single PDF or Word file, and then send it to ronnie.berntsson@umu.se. It is important that you write “postdoc application T4SS” in the subject line of the email.

 

The application should be submitted latest on the 5th of February, 2018. The duration of the fellowship is 2 years. Starting date according to agreement. For further information, please contact ronnie.berntsson@umu.se.

 

Please also see our websites: