Ronnie Berntsson is as of now a Wallenberg Molecular Medicine Fellow

As of 1st of December Ronnie Berntsson has started as a Wallenberg Molecular Medicine Fellow at Umeå University.

New Integrated Structural Biology article: “Formation of a translocation competent protein complex by a dynamic wrap-around binding mechanism.”

This paper from the Wolf-Watz lab describes the discovery of a fundamentally new mechanism underlying protein-protein interactions. The chaperone-binding domain of the Yersinia effector protein YopH was found to lose its globular structure upon formation of a wrap-around architecture with its chaperone SycH. The mechanism is best described as a coupled binding and disordering event. The finding was enabled by an integrated structural biology approach by a five-lab effort and centered on NMR, SAXS and computational chemistry.

The article is published in Journal of Molecular Biology (2018), 430, 3157.

PhD student position available in the group of Ronnie Berntsson

We have a PhD student position available, for structural and functional studies of bacterial Type 4 Secretion Systems.
We are looking for an enthusiastic and highly motivated individual who has an interest in large protein machineries. We use biochemistry, molecular biology, x-ray crystallography and cryo-EM to study Type 4 Secretion Systems, mainly of Gram-positive origin.


The Berntsson lab is part of the integrated structural biology network at Umeå University, and from the 1st of December also part of the Wallenberg Center for Molecular Medicine. We are well equipped with state of the art technologies, both for crystallography and EM, including a nanodrop crystallisation robots, Formulatrix crystallisation hotel, an EM facility with Titan Krios and Scios Dualbeam for FIB-milling, as well as other strong facilities.


For further information, and to apply, please go to the official ad:


Informal inquiries about the position can be directed to me at ronnie.berntsson@umu.se. Applications must be sent in via the online recruitment system, with a deadline at 7th of December.

PhD defence Artur Dingeldein

On June 1st Artur Dingeldein successfully defended his PhD thesis.

Congratulations Artur!

New article out: Interspecies Variation between Fish and Human Transthyretins in Their Binding of Thyroid-Disrupting Chemicals

Zhang J, Grundström C, Brännström K, Iakovleva I, Lindberg M, Olofsson A, Andersson PL, Sauer-Eriksson AE.

Environ Sci Technol. 2018, 52, 11865-11874.

New article out: Structure-Based Design of Inhibitors Targeting PrfA, the Master Virulence Regulator of Listeria monocytogenes.

Kulén M, Lindgren M, Hansen S, Cairns AG, Grundström C, Begum A, van der Lingen I, Brännström K, Hall M, Sauer UH, Johansson J, Sauer-Eriksson AE, Almqvist F. J Med Chem. 2018 May 10;61(9):4165-4175.

New article out: PrgB Promotes Aggregation, Biofilm Formation, and Conjugation through DNA Binding and Compaction

The Berntsson group just published a new article titled “PrgB Promotes Aggregation, Biofilm Formation, and Conjugation through DNA Binding and Compaction”, with the first author Dr. Andreas Schmitt. Check it out here at Molecular Microbiology.

 

Practical Course on Rapid Cloning, Protein Expression, and Purification – 28/2-9/3 2018

Practical Course on Rapid Cloning, Protein Expression, and Purification  

CPEP 18 – 3 ECTS, 28th  February – 9th March 2018

  1. The deadline is extended until 16 February
  2. The course is Free of Charge the fee has been cancelled
    (acceptance  is on a first come first serve basis)

Max number of participants 12.

More information on our course website here:

http://www.kbc.umu.se/english/courses/cpep-course/

Contact and course organiser: Uwe.Sauer@umu.se, Protein Expertise Platform at Umeå University (PEP)

PhD defence Roland Locmelis

On February 5th Roland Locmelis successfully defended his PhD thesis.

Congratulations Roland!

PhD defence: Roland Locmelis, 2018-02-05

Titel: “Structural biology studies of thylacoid lumen proteins required for photosystem II assembly and function”

Date: 5th of February

Time: 10:00

Place: N430, Naturvetarhuset UmU

Supervisor: Uwe H. Sauer